A collision on the Barnby bends between Lowestoft and Beccles resulted in delays for motorists on Saturday evening.
It is understood that the A146 was closed in both directions after three vehicles collided just before 5pm.
Diversions were in place through Mutford and surrounding areas.
A spokesman for the East of England Ambulance Service Trust said: 'An ambulance and a rapid response vehicle attended and treated two patients.
'A man in his 60s with chest pain and a woman treated for shock were taken to James Paget Hospital for further care.'
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